RESEARCH |
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Comprehension and control of aging, infection and microbiota
Using C. elegans and mice as model organisms, we are studying the mechanisms of aging and infection and how to control them. In recent years, it has become clear that inflammation is closely related not only to infection but also to various chronic diseases, and we are focusing on the possibility of using intestinal bacteria to regulate inflammation.
Prevention and alleviation of the pathophysiology of inflammatory bowel disease
Prevention and alleviation of the pathophysiology of inflammatory bowel disease, which has been increasing in recent years, is one of the most important issues. Although E. coli is often highlighted for its diarrheagenic properties, we have found that there is a group of E. colistrains that show inhibitory activity in the induction of inflammatory cytokines. We will also search for enterobacterial species and strains that inhibit inflammation.
Lifespan extension by activating the mitochondrial UPR
Mitochondria are closely related to aging and are a possible target for the control of aging. We have identified pharmaceutical compounds that extend lifespan by activating the mitochondrial UPR through screening using C. elegans. C. elegans is one of the effective model organisms that can provide a simple and rapid approach to phenomena that cannot be evaluated at the cellular level such as lifespan.
PUBLICATIONS |
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CONTACT |
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| Eriko Kage-Nakadai, Ph.D. Professor |
e-mail: nakadai(at)infront.kyoto-u.ac.jp |
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| Institute for Life and Medical Sciences, Kyoto University |
53 Shogoin Kawahara-cho, Sakyo-ku, |